![]() The effect size of the total volume was small in capsaicin and capsaicin plus caffeine (d = 0.62 e d = 0.47, respectively), and trivial in the caffeine condition (d = 0.15). ![]() ![]() No significant differences were found in RPE (p > 0.05) between the experimental conditions. Volunteers were asked about the occurrence of side effects, right after exercise and 24 h after supplementation. RPE was registered at the end of each set. After supplementation, the volunteers completed four sets of back squats until failure, at 70% of one-repetition maximum, with 90 s of rest interval between sets. Each volunteer went through four experimental conditions: supplemented with capsaicin (12 mg), caffeine (400 mg), capsaicin plus caffeine (12 mg and 400 mg, respectively), or placebo. This was a crossover, randomized, double-blind study. Methods: Eleven men (21.5 ± 2.1 years, 1.75 ± 0.08 m, 79.64 ± 10.1 kg), trained in resistance training (experience of 4.5 ± 2.6 years, weekly frequency 5 ± 0.8 days) were recruited. Overall, capsaicin has great potential for becoming a first- or second-line treatment for neuropathic pain, and for becoming a therapeutic option for many other neuropathic pain-related disease states.Ībstract Aim: This study aimed to evaluate the acute supplementation effects of capsaicin, caffeine, and the combined capsaicin plus caffeine on total volume (total repetitions x weight lifted), rate of perceived exertion (RPE), and side-effects on resistance training. For these reasons, a better treatment approach to neuropathic pain is greatly needed. Multiple treatment options may be attempted, while ultimately leaving patients with refractory neuropathic pain. The response to current treatment of neuropathic pain is only modest relief of symptoms. When all pharmacological agents fail to relieve the pain, interventional strategies can be considered, such as neural blocks, spinal cord stimulation, and intrathecal administered medications. It is concluded that pure capsaicin is not active in the standard battery of genotoxicity assays recommended by the International Conference on Harmonisation for evaluation of new medicines earlier reported in vitro genotoxic activity is probably associated with mutagenic impurities in commercial grades of the material.Capsaicin is a natural substance used to treat neuropathic pain because of its ability to be used in a more direct form on patients and efficiently treat their pain without the amount of side effects seen in the use of oral medications.Ĭurrently, the treatments for neuropathic pain are, control of the underlying disease process, then focused on symptomatic relief with pharmacotherapy, topical analgesics, or other interventions. In addition, no evidence of cytotoxicity or genotoxicity was seen in the rat bone marrow micronucleus test, where systemic exposure to pure capsaicin was achieved using the subcutaneous route and a rising dose toleration protocol. The results confirm the absence of genotoxic activity of high-purity capsaicin in the bacterial mutation and chromosome aberration tests. The purpose of the present study, where a series of standard assays were performed in accordance with the Organisation for Economic Cooperation and Development guidance, was to clarify earlier conflicting reports concerning potential genotoxicity of capsaicin prior to administering it to patients in an injectable form. Most recently, injection of pure capsaicin has been proposed as a means of relieving a variety of debilitating diseases, in which case tissues would receive relatively high and direct exposure. ![]() There is widespread dietary exposure to capsaicin in the form of chili peppers, while capsaicin's analgesic qualities have led to increased use of a topical herbal remedy in various impure forms.
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